Creamy Cajun Chicken Pasta with Parmesan, Garlic, and Mozzarella

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There’s something irresistible about a bowl of creamy pasta loaded with bold flavors and topped with golden seared chicken. This Creamy Cajun Chicken Pasta with Parmesan, Garlic, and Mozzarella is a full-on comfort food experience. The rich sauce is infused with garlic and Cajun spices, perfectly clinging to tender pasta, while the juicy, seasoned chicken adds just the right amount of smokiness and heat.

Whether you’re cooking for a crowd or making a cozy weeknight dinner, this dish is a guaranteed showstopper. The cheesy blend of mozzarella and parmesan melts into the creamy base, creating that luscious, velvety texture you dream of. And the best part? It all comes together without needing to be a professional chef. Let’s dive into what makes this dish a favorite.

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What Kind of Cajun Seasoning Should I Use?

The Cajun seasoning is what brings this pasta to life. Opt for a store-bought blend if you’re short on time, but if you’re feeling adventurous, try making your own mix with paprika, cayenne, garlic powder, onion powder, oregano, thyme, salt, and pepper. A smoky Cajun seasoning enhances the charred crust on the chicken and deepens the flavor of the sauce.

Balance is key—too much heat can overwhelm the creamy elements, while too little can make it bland. Start with a modest amount and adjust as you go. You want the seasoning to accent the sauce, not dominate it.

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Ingredients for the Creamy Cajun Chicken Pasta with Parmesan, Garlic, and Mozzarella

Chicken Breast: The protein star of the dish, seasoned and pan-seared for that delicious crispy crust.

Penne Pasta: Holds the creamy sauce beautifully and provides hearty texture.

Cajun Seasoning: Brings bold, spicy flavor and that signature Southern kick.

Garlic: Fresh minced garlic is key to infusing the cream sauce with a savory aroma.

Heavy Cream: Creates the luxurious creamy base of the sauce.

Mozzarella Cheese: Adds creamy meltiness and stretchy texture to each bite.

Parmesan Cheese: Gives the sauce a salty, umami-rich finish that balances the heat.

Butter & Olive Oil: Used for sautéing and adding richness to the sauce.

Parsley: For a pop of color and a hint of freshness at the end.

Salt & Pepper: Essential for seasoning each component just right.

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How To Make the Creamy Cajun Chicken Pasta with Parmesan, Garlic, and Mozzarella

Step 1: Cook the Pasta

Bring a pot of salted water to a boil. Cook the penne pasta according to package directions until al dente. Drain and set aside.

Step 2: Season and Sear the Chicken

Pat chicken breasts dry and season both sides generously with Cajun seasoning, salt, and pepper. Heat olive oil in a large skillet over medium-high heat. Sear chicken for 4–5 minutes per side or until golden brown and cooked through. Remove and let rest before slicing.

Step 3: Make the Cajun Cream Sauce

In the same skillet, lower the heat to medium. Add butter and minced garlic. Sauté until fragrant, about 1 minute. Pour in heavy cream and stir, scraping up any brown bits. Add mozzarella and parmesan, stirring until smooth and creamy.

Step 4: Combine Pasta and Sauce

Add cooked pasta to the skillet and toss to coat in the sauce. Simmer on low for 1–2 minutes to let the flavors meld.

Step 5: Serve

Slice the cooked chicken and place it over the creamy pasta. Garnish with fresh parsley and extra parmesan if desired.

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How to Serve and Store Creamy Cajun Chicken Pasta

Serve this dish hot and fresh, straight from the pan to the plate. A sprinkle of chopped parsley and extra parmesan on top brings both color and flavor. Pair it with garlic bread or a light salad to balance the richness.

To store, transfer leftovers into an airtight container and refrigerate for up to 3 days. To reheat, add a splash of cream or milk to loosen the sauce and warm gently over medium heat. Avoid microwaving at high temps to prevent the cheese from separating.

Frequently Asked Questions

How spicy is this pasta?

That depends on the Cajun seasoning you use. Start mild, then build heat to your liking.

Can I use a different pasta shape?

Yes! Penne is great, but rotini, rigatoni, or fettuccine work wonderfully too.

Can I substitute the heavy cream?

You can use half-and-half for a lighter version, though it won’t be as rich.

What protein alternatives can I use?

Shrimp or andouille sausage are delicious swaps that still complement the Cajun flavor.

Can I make this dish ahead of time?

Yes, prepare everything except combining the pasta and sauce. Mix them just before serving for the best texture.

What can I serve with this pasta?

Garlic knots, roasted vegetables, or a crisp green salad make excellent sides.

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Want More Pasta Ideas with a Kick?

If you love this Creamy Cajun Chicken Pasta, you’ll want to try more bold, cheesy dinners like these:

• Garlic Butter Chicken with Creamy Ricotta Alfredo Pasta
• Creamy Garlic Parmesan Tortellini with Chicken and Broccoli
• Bowtie Pasta with Creamy Velveeta Beef Sauce
• Garlic Parmesan Beef Spaghetti Pasta
• Creamy Garlic Butter Chicken and Rotini in Parmesan Sauce

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And let me know in the comments how yours turned out! Did you add shrimp or keep it classic with chicken? Did you sneak in some veggies?

I love hearing how others make these recipes their own. Ask any questions below—we’re here to cook smarter together!

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