Chicken Bubble Biscuit Bake Casserole

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If you’re looking for the kind of meal that wraps your whole kitchen in warm, savory aromas and makes everyone ask, “What’s cooking?” — this Chicken Bubble Biscuit Bake Casserole is it. Golden, cheesy, and bubbling with creamy chicken goodness, it’s a cozy, family-favorite dish that delivers comfort in every bite.

Each spoonful is layered with tender chicken, rich creamy sauce, buttery biscuits, and a generous blanket of melted cheddar. It’s like chicken pot pie met cheesy pull-apart bread and decided to become the easiest weeknight dinner ever.

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What Kind of Biscuits Should I Use?

Refrigerated biscuit dough works beautifully here—specifically the “buttermilk” variety for its flavor and flakiness. You want biscuits that puff up nicely and soak in all the creamy sauce without getting soggy. Pillsbury Grands are a popular go-to, but feel free to use any flaky biscuit dough you like.

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Ingredients for the Chicken Bubble Biscuit Bake Casserole

Cooked Chicken: This casserole is a great way to use leftover rotisserie or baked chicken. Shredded chicken blends easily into the creamy base and ensures hearty bites throughout.

Refrigerated Biscuit Dough: Chopped into quarters, the biscuits bubble up to create a fluffy, golden topping that contrasts the creamy filling underneath.

Cream of Chicken Soup: The backbone of the creamy sauce. It adds flavor and binds everything together for a rich, comforting texture.

Sour Cream: Adds a tangy creaminess that balances the richness of the soup and cheese.

Cheddar Cheese: Both mixed in and sprinkled on top, cheddar adds sharp, melty goodness and that picture-perfect golden crust.

Milk: Thins the sauce just enough to coat everything without becoming too runny.

Seasonings: Garlic powder, black pepper, and onion powder give the casserole a savory depth without overpowering the chicken.

Cooked Bacon (Optional): For added smoky crunch, sprinkle crumbled bacon over the top just before serving.

Fresh Parsley: A sprinkle of fresh herbs at the end brings brightness and color contrast to all that cheesy richness.

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How To Make the Chicken Bubble Biscuit Bake Casserole

Step 1: Prep the Ingredients

Preheat your oven to 350°F (175°C). Lightly grease a 9×13-inch baking dish. Chop the cooked chicken into bite-sized pieces and cut the biscuit dough into quarters.

Step 2: Mix the Creamy Base

In a large bowl, whisk together the cream of chicken soup, sour cream, milk, garlic powder, onion powder, and black pepper. Stir in about half of the shredded cheddar cheese.

Step 3: Combine Chicken and Biscuits

Fold in the chopped chicken and biscuit pieces, making sure every piece is coated in the creamy mixture.

Step 4: Transfer to Baking Dish

Pour the mixture into the prepared baking dish, spreading it out evenly. Sprinkle the remaining cheddar cheese over the top.

Step 5: Bake to Golden Perfection

Bake uncovered for 35-40 minutes, or until the biscuits are cooked through and the top is golden and bubbly. You can check the biscuits by inserting a toothpick into the center—it should come out clean.

Step 6: Add Bacon and Parsley

Once out of the oven, sprinkle crumbled bacon and freshly chopped parsley on top. Let it rest for 5 minutes before serving.

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How to Serve and Store Chicken Bubble Biscuit Bake Casserole

This dish is best served warm from the oven when the biscuits are fluffy and the cheese is still melty. Pair it with a simple green salad or roasted veggies for a complete meal.

To store leftovers, let the casserole cool completely, then cover tightly or transfer to an airtight container. Refrigerate for up to 4 days. To reheat, use the oven or microwave—adding a splash of milk helps retain creaminess.

You can also freeze this casserole before baking. Assemble everything, cover with foil, and freeze for up to 2 months. Thaw overnight in the fridge before baking as usual.

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Frequently Asked Questions

Can I use raw chicken instead of cooked?

No, the chicken needs to be fully cooked before adding to the casserole. Raw chicken won’t have enough time to cook through safely in this recipe.

What can I use instead of sour cream?

Plain Greek yogurt or cream cheese can work in a pinch. They add similar tang and creaminess.

Are there other cheese options besides cheddar?

Yes! Monterey Jack, mozzarella, or a blend of cheeses work great. Choose one that melts smoothly.

Can I make this casserole ahead of time?

Absolutely. Assemble everything, cover, and refrigerate for up to 24 hours before baking. You may need to add 5-10 minutes to the baking time.

How do I know the biscuits are fully cooked?

Insert a toothpick into one of the center biscuits. If it comes out clean and the biscuit feels firm, it’s ready.

Is this casserole spicy?

Not at all. It’s mild and kid-friendly, but you can add red pepper flakes or hot sauce for a kick.

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Want More Casserole Ideas?

If this Chicken Bubble Biscuit Bake hit the comfort food spot, you’ll love these other cozy casseroles from my kitchen:

• Try the hearty and cheesy Bowtie Pasta with Creamy Velveeta Beef Sauce for a beefy pasta spin.
• This Garlic Butter Chicken with Creamy Ricotta Alfredo Pasta is rich and restaurant-worthy.
• For something classic with a cheesy twist, check out the Cheesy Broccoli Rice Casserole.
• Looking for a fun pasta fusion? You’ll love the One Skillet Spicy Buffalo Ranch Chicken Pasta.
• And don’t miss my savory Deep Hamburger Sausage Pepperoni Pie for a meaty, pizza-style casserole experience.

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📌 Save this recipe to your Pinterest dinner board so you can come back to it any time: Life with Nina Pinterest

And let me know in the comments how yours turned out! Did you add bacon? Try it with mozzarella? Add veggies? I love seeing how you make these recipes your own.

Questions welcome—let’s keep the kitchen fun and flavorful!

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