Creamy Velveeta Penne Pasta with Cajun Beef Alfredo Sauce

WANT TO SAVE THIS RECIPE?

If you’re in the mood for an indulgent dinner that delivers bold, cheesy flavor with a spicy kick, this Creamy Velveeta Penne Pasta with Cajun Beef Alfredo Sauce is calling your name. Imagine tender penne pasta coated in creamy Velveeta cheese sauce, topped with a rich Cajun-spiced ground beef and Alfredo combo. It’s weeknight comfort food elevated with southern flair, and it’s perfect for when you’re craving something hearty, cheesy, and unapologetically satisfying.

The luscious Alfredo sauce gets a smoky twist from Cajun seasoning, adding depth to the velvety base. Ground beef brings a savory, meaty contrast to the smooth pasta, and every bite is layered with creamy cheese and heat. It’s a one-bowl masterpiece that’s quick to pull together yet impressive enough to serve guests. Pair it with garlic bread or a simple salad, and dinner is done.

---

What Kind of Pasta Should I Use?

Penne pasta works beautifully in this recipe because the ridges hold onto the creamy cheese and Cajun Alfredo sauce, making every bite rich and flavorful. Rigatoni or ziti would also work if you’re out of penne—just stick to a short, tubular pasta that captures the sauce in every nook.

---

Ingredients for the Creamy Velveeta Penne Pasta with Cajun Beef Alfredo Sauce

• Penne Pasta: The perfect pasta shape to hold the thick cheese and beef sauce.
• Ground Beef: Adds meaty, savory richness that contrasts the creamy cheese sauce.
• Velveeta Cheese: This is where the creaminess comes in! Velveeta melts like a dream and gives that signature silky texture.
• Heavy Cream: Essential for creating the Alfredo base and keeping the sauce indulgently smooth.
• Butter: Adds richness to the sauce and helps cook the beef.
• Garlic: Provides a fragrant base to the sauce, deepening the flavor.
• Cajun Seasoning: The key spice blend that infuses the dish with smoky heat and southern soul.
• Salt & Pepper: For seasoning and balancing flavors.
• Mozzarella (optional): A gooey, stretchy topping when broiled for added cheesiness.
• Fresh Parsley (optional): For garnish and a fresh pop of color.

---

How To Make the Creamy Velveeta Penne Pasta with Cajun Beef Alfredo Sauce

Step 1: Cook the Pasta

Bring a large pot of salted water to a boil. Add the penne pasta and cook until al dente according to package instructions. Drain and set aside.

Step 2: Brown the Beef

In a large skillet over medium-high heat, melt 1 tablespoon of butter. Add ground beef, season with a pinch of salt and pepper, and cook until browned and cooked through. Drain excess grease if needed.

Step 3: Build the Cajun Alfredo Base

In the same skillet with the cooked beef, add minced garlic and cook for 1 minute until fragrant. Pour in the heavy cream and bring to a gentle simmer. Stir in Cajun seasoning and mix well.

Step 4: Melt in the Velveeta

Lower the heat and add the cubed Velveeta cheese. Stir continuously until fully melted and the sauce becomes smooth and creamy. Taste and adjust seasoning if needed.

Step 5: Combine Pasta and Sauce

Add the drained penne pasta directly into the sauce. Toss everything together until the pasta is evenly coated and saucy.

Step 6: Optional Broil Finish

For extra cheesiness, transfer the pasta to an oven-safe dish, sprinkle with shredded mozzarella, and broil for 2-3 minutes until bubbly and golden. Garnish with chopped parsley.

---

How to Serve and Store This Creamy Velveeta Pasta

Serve this dish hot and fresh out of the pan, topped with melty mozzarella and a sprinkle of fresh parsley. It’s perfect as a standalone meal but pairs wonderfully with garlic knots, crusty bread, or a crisp side salad.

To store leftovers, let the pasta cool completely and transfer it to an airtight container. It will stay good in the fridge for up to 3–4 days. To reheat, add a splash of milk or cream before microwaving or warming on the stovetop to revive the sauce’s creaminess.

Freezing isn’t ideal for Velveeta-based sauces as they may split upon thawing, but if needed, freeze in single-serve portions and reheat gently.

---

Frequently Asked Questions

Can I use a different cheese instead of Velveeta?

Yes, you can use American cheese or cheddar, but Velveeta gives the smoothest melt and creamiest texture.

Is this recipe spicy?

The heat level depends on your Cajun seasoning. Use a mild blend or reduce the amount if you’re sensitive to spice.

Can I make this ahead of time?

You can prep the sauce and pasta separately ahead of time and store them in the fridge. Combine and heat when ready to serve.

What can I substitute for heavy cream?

Half-and-half or evaporated milk can be used, though the sauce will be slightly less rich.

Can I make it vegetarian?

Absolutely! Swap the ground beef with plant-based meat or even mushrooms for a veggie twist.

How can I make this gluten-free?

Use gluten-free penne pasta and double-check that your Cajun seasoning and Velveeta are certified gluten-free.

---

Want More Pasta Dinner Ideas?

If this creamy Cajun pasta became an instant favorite, here are more delicious recipes you’ll want to try next:

• Garlic Butter Chicken with Creamy Ricotta Alfredo Pasta for a rich, mellow twist.
• One-Pot Creamy Chicken Pasta Dinner when you want a fast cleanup.
• Garlic Parmesan Beef Spaghetti Pasta for a nostalgic, beefy classic.
• Bowtie Pasta with Creamy Velveeta Beef Sauce to switch up the pasta shape.
• One Skillet Sweet Spicy Sticky Chicken Pasta if you love bold, tangy flavors.

---

Save This Pin + Share Your Results

📌 Save this recipe to your Pinterest dinner board so you can find it when cravings hit.

And when you do try it, let me know how it turned out! Did you go heavy on the Cajun heat? Add more cheese? I love seeing your takes on these cozy dishes.

For more of my daily recipe creations, follow along on Pinterest – Life with Nina.

---

Print