Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

by Nina Johnson August 16, 2025

Golden-crusted chicken paired with tender twisted pasta drenched in a rich mozzarella Alfredo sauce makes this dish the perfect comfort food. The Cajun seasoning brings warmth and depth, while the creamy cheese balances every bite with indulgence. It’s the kind of dinner that feels both hearty and special without being overly complicated.

Whether you’re cooking for your family on a busy weeknight or looking to impress guests, this pasta is versatile and satisfying. The crispy chicken adds texture, the Cajun spices add boldness, and the Alfredo sauce creates the velvety finish everyone craves.

What Kind of Pasta Works Best for This Dish?

Rotini or fusilli pasta is ideal because their spiral shape holds onto the creamy Alfredo sauce beautifully. The ridges allow the sauce to cling to every bite, ensuring you enjoy the perfect balance of pasta and flavor.

Ingredients for the Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

Chicken breasts – Tender, juicy, and perfect for holding the Cajun crust.
Cajun seasoning – Adds smoky, spicy flavor that balances the creamy Alfredo.
Breadcrumbs – Creates the golden crunch on the chicken.
Parmesan cheese – Mixed with breadcrumbs for extra flavor.
Rotini pasta – Twisted shape that locks in sauce.
Butter – The base of the Alfredo sauce.
Garlic – Infuses the sauce with a savory aroma.
Heavy cream – Makes the Alfredo rich and silky.
Mozzarella cheese – Melts into the sauce for gooey creaminess.
Parsley – Adds a fresh garnish and touch of color.

How To Make the Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

Step 1: Prepare the Chicken

Season chicken breasts generously with Cajun seasoning. Coat them in a breadcrumb and Parmesan mixture, pressing firmly to create a crust.

Step 2: Cook the Chicken

In a skillet over medium heat, add a drizzle of oil and cook the chicken until golden brown on both sides and fully cooked inside. Remove and let rest before slicing into strips.

Step 3: Boil the Pasta

Cook rotini pasta according to package instructions until al dente. Drain, but reserve about ½ cup of pasta water for the sauce.

Step 4: Make the Alfredo Sauce

In the same skillet, melt butter and sauté minced garlic until fragrant. Pour in heavy cream, whisk, and let it simmer for 3–4 minutes. Gradually add shredded mozzarella, stirring until smooth and creamy. Use reserved pasta water if the sauce needs thinning.

Step 5: Combine Pasta and Sauce

Add the cooked pasta into the Alfredo sauce and toss until fully coated. Garnish with parsley for freshness.

Step 6: Assemble the Dish

Slice the Cajun-crusted chicken and serve it over the creamy twisted pasta. Finish with an extra sprinkle of Parmesan and parsley if desired.

Serving and Storing Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

This dish is best served immediately while the chicken is crispy and the Alfredo sauce is creamy. Pair it with a side of garlic bread or a simple green salad to balance the richness. If serving later, store the chicken and pasta separately to maintain texture.

For storage, refrigerate leftovers in airtight containers. The pasta will last up to 3 days, and the chicken up to 4. Reheat the pasta gently on the stovetop with a splash of cream or milk to revive the sauce’s creaminess.

Frequently Asked Questions

Can I use a different pasta shape?

Yes! Penne, rigatoni, or even fettuccine work well if you don’t have rotini.

Is there a lighter alternative to heavy cream?

You can swap in half-and-half or whole milk for a lighter sauce, though it won’t be as thick.

Can I make this dish spicier?

Absolutely—add extra Cajun seasoning or a pinch of cayenne pepper for more heat.

What cheese can replace mozzarella?

Parmesan or provolone are great substitutes that still deliver creamy richness.

How do I keep the chicken crispy?

Keep the chicken separate until just before serving, and avoid reheating it directly in the sauce.

Want More Pasta Dinner Ideas?

If this creamy Cajun chicken pasta won you over, you’ll love these other savory pasta recipes from my collection:

Garlic Butter Chicken with Creamy Ricotta Alfredo Pasta – for a silky, cheese-packed meal.
Bowtie Pasta with Creamy Velveeta Beef Sauce – comfort food with a hearty twist.
One-Skillet Cheesy Spicy Garlic Butter Steak Pasta – bold flavors with a steakhouse feel.
One-Pot Creamy Spicy Cajun Chicken Sausage Mac – Cajun comfort meets cheesy pasta goodness.
Creamy Garlic Parmesan Tortellini with Chicken and Broccoli – a veggie-filled creamy delight.

📌 Save this recipe to your Pinterest dinner board so you can make it again whenever the craving hits.

I’d love to hear how your version turned out! Did you add extra spice to the Cajun chicken? Maybe swapped mozzarella with cheddar? Share your tweaks and tips—I enjoy seeing how everyone makes these recipes their own.

For more daily meal inspiration, visit my Pinterest: Life with Nina Recipes.