Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

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Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce is what weeknight comfort food dreams are made of. A smoky-spiced, juicy blackened chicken breast sits proudly atop a tangle of spaghetti, all generously coated in a garlicky mozzarella cheese sauce that pulls and stretches with every twirl of the fork. It’s rich, satisfying, and packed with Southern-inspired heat that’ll leave your taste buds buzzing.

This dish comes together in under an hour and hits every craving at once: cheesy, creamy, spicy, and meaty. Whether you’re making this for a cozy dinner or trying to impress guests with minimal effort, this spaghetti will deliver flavor beyond the ordinary. Think Alfredo, but with attitude.

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What Kind of Spaghetti Should I Use?

Classic spaghetti noodles work perfectly here to soak up every drop of that luxurious garlic mozzarella sauce. If you’re looking to switch it up, linguine or fettuccine are great alternatives that hold sauce well. Just avoid super thin pastas like angel hair, which can get overwhelmed by the richness.

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Ingredients for the Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

Chicken Breasts – The star of the dish. Boneless, skinless chicken breasts take on Cajun seasoning beautifully and sear to a perfect golden crust.

Cajun Seasoning – Brings smoky, peppery heat to balance the richness. Use a store-bought blend or make your own if you like control over the spice.

Spaghetti – This neutral pasta acts as the vehicle for all that creamy, cheesy flavor.

Garlic – Minced garlic adds depth and an irresistible aroma that permeates the sauce.

Heavy Cream – Essential for creating a rich, velvety base that clings to the pasta.

Mozzarella Cheese – The melty magic. Shredded mozzarella brings gooeyness and mild cheesy flavor.

Butter – Helps with the base of the sauce and adds richness.

Parsley – Fresh or dried, parsley cuts through the heaviness with a pop of color and freshness.

Salt and Pepper – Essential seasonings to round out and balance all the flavors.

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How To Make the Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

Step 1: Season and Sear the Chicken

Pat chicken breasts dry, then rub both sides generously with Cajun seasoning. In a hot skillet with a drizzle of oil, sear each breast over medium-high heat for 5–6 minutes per side until golden brown and cooked through. Remove and let rest before slicing.

Step 2: Cook the Spaghetti

While the chicken is cooking, boil spaghetti in salted water according to package instructions. Drain and set aside, saving 1/2 cup of pasta water.

Step 3: Create the Garlic Butter Base

In the same skillet, melt butter over medium heat. Add minced garlic and sauté until fragrant, about 1 minute. Do not let it brown.

Step 4: Build the Sauce

Pour in the heavy cream and stir well. Reduce the heat and let it simmer for 2–3 minutes. Slowly stir in shredded mozzarella, letting it melt and turn the sauce into a smooth, creamy dream.

Step 5: Combine Pasta and Sauce

Add the cooked spaghetti to the skillet with the sauce. Toss well to coat, adding a bit of reserved pasta water if needed to loosen the sauce.

Step 6: Assemble and Serve

Plate the creamy spaghetti and top with sliced Cajun chicken. Sprinkle with parsley and extra mozzarella if desired. Serve hot and melty.

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How to Serve and Store Your Creamy Cajun Chicken Spaghetti

Serve this dish hot from the skillet, plated high with generous slices of Cajun chicken right on top. A sprinkle of fresh parsley adds a pop of color, while a little extra mozzarella gives it that irresistible cheesy pull. Pair with a crisp side salad or garlic bread to round out the meal.

To store leftovers, let the pasta cool completely, then place in an airtight container. It keeps well in the fridge for up to 3 days. Reheat gently on the stove with a splash of milk or cream to bring back that velvety texture. Avoid microwaving on high, which can make the cheese sauce separate.

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Frequently Asked Questions

Can I use a different type of pasta?

Absolutely! Linguine, fettuccine, or even penne will work great with this sauce. Just stick with shapes that can hold creamy sauces well.

What can I substitute for heavy cream?

You can use half-and-half or even whole milk, but note the sauce will be less rich and creamy. A bit of cream cheese can help thicken if needed.

Is there a vegetarian version of this recipe?

Yes—swap the chicken for sautéed mushrooms or roasted cauliflower and skip the Cajun seasoning or use a milder blend.

Can I make this dish ahead of time?

It’s best fresh, but you can make the chicken and sauce ahead and reheat gently, then toss with pasta right before serving.

How spicy is Cajun seasoning?

It depends on the brand. Some are mild while others bring serious heat. Taste and adjust before adding to the whole dish.

Can I freeze leftovers?

Not recommended. The mozzarella sauce can become grainy when frozen and thawed. Stick to refrigerating and enjoying within a few days.

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Want More Pasta Ideas with a Kick?

If you’re into bold flavors like this Creamy Cajun Chicken Spaghetti, here are a few other pasta favorites you’ll want to try next:

• Garlic Butter Chicken with Creamy Ricotta Alfredo Pasta
• One Skillet Spicy Buffalo Ranch Chicken Pasta
• Sweet Tangy Honey Dijon Chicken Pasta
• Cajun Ranch Shrimp and Sausage Pasta Skillet
• One Pot Creamy Spicy Cajun Chicken Sausage Mac

These will give your weeknight dinners the flavor twist they’ve been craving.

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📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you add mushrooms? Swap the mozzarella for gouda? Spice it up with extra Cajun heat?

I love seeing your creations and how you make these recipes your own. Tag me on Pinterest too, where I share my daily cooking inspiration: Life with Nina on Pinterest

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