Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce is the kind of comfort food that instantly feels like a warm hug. This one-skillet pasta dish combines tender bites of spiced chicken, rotini noodles that hold onto every bit of sauce, and a velvety Alfredo blend that’s rich with mozzarella and Cajun flair. It’s bold, creamy, cheesy, and perfect for weeknights when you want something cozy but crave something with a little spice.

The Cajun seasoning brings just the right amount of smoky heat, and when balanced with the creamy Alfredo and gooey mozzarella, it becomes the kind of meal that keeps you coming back for seconds. Whether you’re feeding a hungry family or meal prepping for the week, this pasta delivers both flavor and comfort effortlessly.

What Kind of Pasta Works Best for Creamy Cajun Chicken?

Rotini is the star here because its spiraled shape is ideal for catching the creamy Alfredo and bits of spice in every bite. However, if you don’t have rotini, penne or cavatappi would also work well thanks to their ridges and tubular design.

Ingredients for the Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

Chicken Breast – Sliced into thin strips, this is the protein base of the recipe and soaks up the Cajun spices perfectly.

Rotini Pasta – Its spiral shape holds onto the Alfredo sauce and spices, making every bite flavorful.

Cajun Seasoning – The heart of the dish’s flavor. Smoky, slightly spicy, and aromatic.

Garlic – Adds warmth and depth to the sauce.

Butter – Creates a rich foundation for the Alfredo and helps sear the chicken.

Heavy Cream – Essential for the creaminess of the Alfredo sauce.

Mozzarella Cheese – Melts into the cream for a gooey, stretchy finish.

Parmesan Cheese – Adds saltiness and sharpness to balance the mozzarella.

Salt & Pepper – For seasoning to taste.

Olive Oil – Helps brown the chicken and garlic to bring out their full flavor.

How To Make the Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

Step 1: Season and Cook the Chicken

Start by slicing your chicken breasts into thin strips and tossing them with Cajun seasoning, salt, and pepper. Heat olive oil and a tablespoon of butter in a large skillet over medium-high heat. Once hot, add the chicken strips and cook until browned and fully cooked through. Remove and set aside.

Step 2: Saute the Garlic

In the same skillet, add another tablespoon of butter and the minced garlic. Saute for about 30 seconds to 1 minute until the garlic is fragrant and lightly golden. Keep it moving so it doesn’t burn.

Step 3: Make the Alfredo Sauce

Lower the heat slightly and pour in the heavy cream, stirring to deglaze the skillet. Let it simmer for 3-4 minutes before adding the mozzarella and Parmesan cheeses. Stir gently until the cheeses melt into a luscious, creamy sauce.

Step 4: Cook the Pasta

While the sauce is simmering, boil the rotini pasta in salted water according to package directions. Drain and reserve 1/4 cup of pasta water.

Step 5: Bring It All Together

Add the cooked pasta and chicken back into the skillet with the Alfredo sauce. Toss everything to coat well. If the sauce feels too thick, add a splash of reserved pasta water to loosen it up.

Step 6: Final Touches

Let everything simmer together for another 2-3 minutes to let the flavors meld. Taste and adjust seasoning with extra Cajun spice or salt if needed.

Serve hot, garnished with extra Parmesan or chopped parsley if desired.

Serving and Storing Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

This creamy pasta is best served immediately while the sauce is hot and silky. Pair it with a crisp green salad or garlic bread to balance the richness. It also makes a great date night meal with a glass of chilled white wine or sparkling water with lemon.

For storing, let the pasta cool completely before transferring it to an airtight container. It keeps well in the refrigerator for up to 4 days. To reheat, warm it on the stovetop with a splash of cream or milk to restore the sauce’s creaminess.

Frequently Asked Questions

Can I use a different type of pasta?

Absolutely! While rotini holds the sauce well, penne, rigatoni, or even fettuccine can be delicious alternatives.

Is it possible to make this dish less spicy?

Yes! You can reduce the amount of Cajun seasoning or use a mild blend to tone down the heat without losing flavor.

Can I make this dish ahead of time?

Yes, but for best texture, prepare the pasta and sauce fresh. You can cook the chicken and store it separately to save time.

What proteins can I use besides chicken?

Shrimp, andouille sausage, or even tofu are great alternatives depending on your preferences.

How do I keep the sauce from getting too thick when reheating?

Add a splash of milk or cream while reheating and stir gently over low heat. This brings the sauce back to its original smoothness.

Can I freeze this pasta?

While technically possible, the cream-based sauce may separate. It’s best enjoyed fresh or refrigerated for a few days.

Want More Pasta Recipes That Hit the Spot?

If you enjoyed this Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce, here are a few more flavor-packed pasta recipes worth checking out:

Garlic Butter Chicken with Creamy Ricotta Alfredo Pasta for a velvety, garlic-loaded twist.
Creamy Garlic Parmesan Tortellini with Chicken and Broccoli if you want a one-pot dinner with some greens.
Bowtie Pasta with Creamy Velveeta Beef Sauce for a beefy, cheesy delight.
One Skillet Cheesy Spicy Garlic Butter Steak Pasta when you’re in the mood for steak with bold flavor.
Sweet Tangy Honey Dijon Chicken Pasta for something sweet, savory, and unexpected.

📌 Save this recipe to your Pinterest dinner board so you can make it again when that creamy, spicy craving hits.

And when you do, let me know how it turned out! Did you add extra spice or sneak in some veggies? Drop a comment below to share your version.

Want more creamy chicken pasta and easy comfort meals? Visit me over on Pinterest @LifeWithNinaRecipes where I share daily recipes you’ll love.

Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

Author: Nina Johnson
Prep Time: 10 minutes
Cook Time: 20 minutes
Total Time: 30 minutes
Yield: 4 servings 1x
Category: Dinner
Method: Stovetop
Cuisine: American

Print Recipe

Description

This Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce is a spicy, cheesy, one-skillet comfort meal. Juicy Cajun-seasoned chicken is tossed with tender rotini pasta and coated in a rich mozzarella Alfredo sauce. Perfect for a hearty family dinner or meal prep favorite, it’s a flavorful twist on classic Alfredo.