Creamy Cajun Chicken Linguine with Spicy Garlic Cheese Sauce

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Golden-seared Cajun-spiced chicken bites paired with a luscious garlic cheese sauce make this Creamy Cajun Chicken Linguine an unforgettable dinner. Every forkful delivers a harmonious blend of smoky spice, velvety cream, and a gentle heat that lingers just long enough to make you want another bite.

The linguine soaks up every drop of the rich sauce, while tender, juicy chicken pieces bring satisfying texture and flavor. It’s the perfect balance of comfort and boldness — an ideal weeknight indulgence that feels like a restaurant-worthy treat.

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What Makes the Perfect Cajun Chicken Linguine?

The magic lies in the seasoning and the sauce. A true Cajun blend should have paprika, garlic, onion, and a little cayenne for that kick. Pairing it with a creamy garlic cheese sauce tames the spice while enhancing every savory note. The contrast between the silky linguine and crispy-edged chicken bites is where the magic happens.

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Ingredients for the Creamy Cajun Chicken Linguine with Spicy Garlic Cheese Sauce

Chicken Breast — Boneless, skinless, and cut into bite-sized pieces for quick, even cooking.

Cajun Seasoning — The star flavor blend that infuses the chicken with warmth and smokiness.

Olive Oil & Butter — For searing the chicken to golden perfection and adding richness to the sauce.

Garlic — Freshly minced to create that irresistible aromatic base.

Heavy Cream — Gives the sauce its indulgent, velvety texture.

Cheddar & Parmesan Cheese — A duo that combines sharpness and nutty depth.

Red Bell Pepper — Adds a pop of sweetness and color to the creamy sauce.

Linguine Pasta — The perfect shape to hold on to the sauce and flavors.

Fresh Parsley — For a fresh, bright garnish that completes the dish.

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How To Make the Creamy Cajun Chicken Linguine with Spicy Garlic Cheese Sauce

Step 1: Season and Sear the Chicken

Pat the chicken pieces dry, then toss them generously with Cajun seasoning. Heat olive oil and butter in a skillet over medium-high heat, then sear the chicken until golden and cooked through. Remove from the skillet and set aside.

Step 2: Build the Flavor Base

In the same skillet, add a little more butter if needed. Sauté minced garlic until fragrant, about 30 seconds, then add diced red bell pepper. Cook until the peppers soften slightly.

Step 3: Make the Creamy Garlic Cheese Sauce

Pour in heavy cream, stirring to incorporate all the browned bits from the pan. Reduce the heat to low and slowly add shredded cheddar and Parmesan, whisking until the sauce is smooth and creamy.

Step 4: Cook the Linguine

While the sauce simmers, cook linguine in salted boiling water until al dente. Drain, reserving about ½ cup of the pasta water.

Step 5: Combine and Finish

Add the cooked linguine to the sauce, tossing to coat. If the sauce is too thick, stir in a splash of reserved pasta water until it reaches the perfect consistency. Top with the Cajun chicken bites and garnish with fresh parsley.

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Serving and Storing This Creamy Cajun Chicken Linguine

Serve hot, ideally in warmed bowls to keep the sauce silky. Pair it with garlic bread or a crisp green salad for balance. Leftovers can be stored in an airtight container in the fridge for up to 3 days. Reheat gently over low heat with a splash of cream or milk to bring the sauce back to life.

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Frequently Asked Questions

Can I use a different pasta shape?

Absolutely! Penne, fettuccine, or even rotini will hold the sauce beautifully.

How can I make it spicier?

Increase the cayenne in your Cajun seasoning or add red pepper flakes to the sauce.

Can I substitute the chicken?

Yes, shrimp or andouille sausage are delicious alternatives.

How do I prevent the cheese sauce from clumping?

Use low heat when adding cheese and stir constantly until smooth.

Is this recipe gluten-free?

It can be! Just use gluten-free pasta and ensure your Cajun seasoning blend is gluten-free.

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Want More Pasta Dinner Ideas?

If you love this creamy, flavorful pasta, you’ll enjoy these other comforting favorites from Life with Nina:

• One-Skillet Cheesy Spicy Garlic Butter Steak Pasta
• Garlic Butter Chicken with Creamy Ricotta Alfredo Pasta
• One-Pot Creamy Spicy Cajun Chicken Sausage Mac
• Garlic Parmesan Beef Spaghetti Pasta

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Save This Pin + Share Your Results

📌 Save this recipe to your Pinterest dinner board so you can find it again when the craving hits.

I’d love to hear how yours turned out! Did you stick with chicken or swap in seafood? Did you go extra spicy or keep it mild? Share your creations and let’s inspire each other.

Find more recipes on my Pinterest Life with Nina.

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