Name: Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce
Prep time: 10 min
Cook time: 20 min
Total time: 30 min
Cuisine: Southern-Inspired
Ingredients: 2 large chicken breasts; 8 oz fettuccine pasta; 1 cup heavy cream; 1 ½ cups shredded mozzarella cheese; 3 cloves garlic, minced; 2 tablespoons butter; 1 tablespoon olive oil; 2 tablespoons Cajun seasoning; 1 tablespoon chopped fresh parsley; ½ teaspoon salt; ¼ teaspoon black pepper

When you’re craving bold flavor and velvety richness in one cozy dish, this Creamy Cajun Chicken Fettuccine delivers in every bite. Imagine fork-twirled ribbons of tender fettuccine tangled in a garlicky, cheesy mozzarella cream sauce, crowned with juicy blackened Cajun chicken. The balance of creamy indulgence and warm spice makes this a comforting weeknight favorite that feels like a restaurant-quality indulgence.

The best part? It comes together surprisingly quickly. Whether you’re cooking to impress dinner guests or just want something comforting and full of flavor, this fettuccine has all the charm of a Southern-inspired pasta night. It’s a must-try for cheese lovers and spice seekers alike.

What Makes the Perfect Cajun Chicken Fettuccine?

It all starts with well-seasoned chicken. Blackened in a hot skillet, the Cajun spices bring out that irresistible smoky char, locking in the juices. Then there’s the sauce—a rich base of garlic, cream, and mozzarella that wraps the pasta in stretchy, cheesy goodness. The key is balancing heat with creaminess, so every bite feels bold but smooth.

Use freshly grated mozzarella if you can—it melts silkier than pre-shredded bags. And a quality Cajun spice blend makes all the difference, so don’t be afraid to customize the heat to your liking.

Ingredients for the Creamy Cajun Chicken Fettuccine

Chicken Breasts: Sliced and seasoned with Cajun spices, this is the heart of the recipe—smoky, juicy, and full of flavor.

Fettuccine Pasta: A wide, sturdy pasta that holds up perfectly to thick cheese sauces.

Heavy Cream: This forms the luxurious base of the sauce and helps all that cheese turn into molten velvet.

Mozzarella Cheese: Choose low-moisture mozzarella for the ultimate gooey melt that coats every strand of pasta.

Garlic: Freshly minced garlic sautéed in butter brings depth and aroma to the sauce.

Butter & Olive Oil: Used to cook the chicken and build the sauce; butter adds richness, and olive oil helps brown the chicken evenly.

Parsley: A sprinkle of fresh chopped parsley for color and a hint of freshness at the end.

Salt & Pepper: Essential seasonings to enhance all the bold flavors.

Cajun Seasoning: The star spice blend—smoky, peppery, and just the right amount of heat.

How To Make the Creamy Cajun Chicken Fettuccine

Step 1: Prepare the Pasta

Bring a large pot of salted water to a boil and cook the fettuccine according to package directions. Reserve 1/2 cup of pasta water, then drain and set aside.

Step 2: Season and Cook the Chicken

Pat the chicken breasts dry and coat generously with Cajun seasoning, salt, and pepper. In a hot skillet over medium-high heat, add olive oil and cook the chicken for 4–5 minutes per side until golden and cooked through. Transfer to a plate and let it rest before slicing.

Step 3: Sauté the Garlic

In the same skillet, reduce the heat to medium. Add butter and the minced garlic. Stir frequently for 1–2 minutes until fragrant, being careful not to burn it.

Step 4: Make the Creamy Sauce

Pour in the heavy cream, stirring gently to combine. Gradually add in the mozzarella, stirring until melted and smooth. If the sauce is too thick, add a splash of the reserved pasta water to reach your desired consistency.

Step 5: Combine with Pasta

Add the cooked fettuccine to the sauce, tossing well to coat every strand in cheesy goodness. Let it simmer for 1–2 minutes so the flavors marry.

Step 6: Top and Garnish

Slice the blackened Cajun chicken and place it over the fettuccine. Garnish with freshly chopped parsley and serve hot with an optional sprinkle of extra Cajun seasoning.

Serving and Storing This Cajun Chicken Fettuccine

This pasta is best served fresh while the sauce is hot and stretchy. Pair it with a crisp green salad or warm garlic bread for a well-rounded dinner. The heat from the Cajun spice and the creamy cheese balance beautifully with something light and crunchy on the side.

To store leftovers, let the dish cool completely before transferring to an airtight container. Refrigerate for up to 3 days. Reheat gently on the stove with a splash of cream or milk to revive the sauce’s texture. Freezing is not ideal due to the dairy-based sauce, which may separate.

Frequently Asked Questions

What kind of Cajun seasoning should I use?

Use a store-bought Cajun blend or make your own with paprika, garlic powder, onion powder, thyme, oregano, cayenne, salt, and pepper. Adjust the cayenne to control the heat.

Can I substitute another cheese for mozzarella?

Yes! Parmesan, Monterey Jack, or even Fontina can work beautifully. Mozzarella gives the best melt, but other cheeses bring great flavor depth.

What if I don’t have heavy cream?

You can substitute with half-and-half or a mix of milk and cream cheese. The texture may be slightly thinner, but still delicious.

Can I use a different pasta?

Absolutely. Penne, linguine, or tagliatelle are all great choices that hold sauce well.

Is this recipe spicy?

It has a medium heat level from the Cajun spices. For milder flavor, reduce the Cajun seasoning or use a mild blend.

How do I make it extra cheesy?

Add more mozzarella or a handful of sharp white cheddar during the sauce step. You can also top the finished dish with cheese and broil for 2 minutes.

Want More Pasta Dinner Ideas?

If this Creamy Cajun Chicken Fettuccine stole your heart, check out these other hearty dishes from my kitchen:

Garlic Butter Chicken with Creamy Ricotta Alfredo Pasta for a luscious twist on alfredo.
Lemon Garlic Butter Chicken Bites with Savory Parmesan Linguine for zesty weeknight comfort.
Bowtie Pasta with Creamy Velveeta Beef Sauce if you love beefy and cheesy in one dish.
Garlic Parmesan Beef Spaghetti Pasta for a bold garlic twist.
Cafeteria Noodles with Garlic Butter Chicken Bites for ultimate nostalgic flavor.

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you amp up the Cajun heat? Did you sneak in extra cheese?

I love seeing your creations and how you make these recipes your own. Have questions or tips? Share them below—let’s keep cooking delicious together.

👉 For more mouthwatering pasta dinners and easy weeknight meals, follow me on Pinterest at Life with Nina.

Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce

Author: Nina Johnson
Prep Time: 10 minutes
Cook Time: 20 minutes
Total Time: 30 minutes
Yield: 4 servings 1x
Category: Dinner
Method: Stovetop
Cuisine: Southern-Inspired

Print Recipe

Description

A rich and indulgent pasta dish featuring tender Cajun-spiced chicken breast, nestled on a bed of fettuccine and smothered in a silky garlic mozzarella cream sauce. This Creamy Cajun Chicken Fettuccine is the perfect weeknight comfort meal packed with bold flavor and irresistible cheesiness.

Instructions

1. Bring a large pot of salted water to a boil. Cook the fettuccine according to package instructions. Reserve ½ cup pasta water, drain, and set aside.

2. Pat chicken breasts dry. Season both sides with Cajun seasoning, salt, and pepper.

3. In a large skillet over medium-high heat, add olive oil and sear chicken for 4–5 minutes on each side until fully cooked and blackened. Remove and let rest.

4. Lower heat to medium. In the same skillet, melt butter and sauté garlic for 1–2 minutes until fragrant.

5. Pour in heavy cream and stir to combine. Slowly add shredded mozzarella and stir until melted and smooth. Use reserved pasta water to adjust thickness if needed.

6. Add cooked fettuccine into the sauce, tossing to coat all noodles evenly.

7. Slice rested chicken and serve over pasta. Garnish with chopped parsley and extra Cajun seasoning if desired.