Cheesy Garlic Cajun Chicken Bowtie Pasta in Alfredo Sauce

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Looking for a meal that brings together bold spices, creamy comfort, and a satisfying bite? This Cheesy Garlic Cajun Chicken Bowtie Pasta in Alfredo Sauce is everything you want in a weeknight dinner. Perfectly seared cajun-seasoned chicken rests over buttery garlic-infused bowtie pasta, all coated in a silky Alfredo sauce with a generous touch of cheese.

This recipe is a beautiful balance between spicy and creamy, with every bowtie noodle holding onto just the right amount of sauce. Whether you’re feeding a hungry family or hosting a casual dinner, this dish is a guaranteed crowd-pleaser. And the best part? It comes together quickly without sacrificing flavor.

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What Kind of Cajun Seasoning Should I Use?

You can go homemade or store-bought! A good Cajun seasoning typically includes paprika, garlic powder, onion powder, cayenne pepper, oregano, thyme, and black pepper. If you’re sensitive to heat, choose a mild blend or adjust the cayenne to your liking. Store-bought blends like Slap Ya Mama or Tony Chachere’s work great too, but keep an eye on the salt level if your Alfredo sauce is already seasoned.

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Ingredients for the Cheesy Garlic Cajun Chicken Bowtie Pasta in Alfredo Sauce

• Chicken Breasts – These are the protein centerpiece. Slicing them thin helps them cook evenly and soak up that Cajun spice.
• Cajun Seasoning – Adds the signature smoky heat that defines this dish. Rub generously onto the chicken.
• Bowtie (Farfalle) Pasta – The fun shape isn’t just for looks; it holds the sauce beautifully.
• Garlic – Fresh minced garlic sautéed in butter forms the aromatic base of the Alfredo.
• Butter – For rich flavor and to start the sauce.
• Heavy Cream – The silky foundation for our Alfredo sauce.
• Parmesan Cheese – Adds nutty depth and helps thicken the sauce.
• Mozzarella Cheese – Brings the gooey, stretchy cheese factor that makes this dish indulgent.
• Parsley – For color and a fresh finish.
• Crushed Red Pepper (Optional) – To dial up the spice if you’re feeling bold.

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How To Make the Cheesy Garlic Cajun Chicken Bowtie Pasta in Alfredo Sauce

Step 1: Season and Sear the Chicken

Generously rub Cajun seasoning over the sliced chicken breasts. Heat a skillet over medium-high heat with a drizzle of olive oil or butter. Sear the chicken on both sides until it’s golden brown and cooked through, about 4–6 minutes per side. Set aside and let it rest before slicing.

Step 2: Boil the Bowtie Pasta

In a large pot, bring salted water to a boil and cook the bowtie pasta until al dente according to package instructions. Drain and set aside, reserving about 1/2 cup of pasta water.

Step 3: Sauté Garlic in Butter

In the same skillet used for the chicken (wipe it clean if needed), melt butter over medium heat. Add minced garlic and sauté until fragrant, about 1 minute. Don’t let it brown.

Step 4: Make the Alfredo Sauce

Pour in the heavy cream and bring it to a low simmer. Stir in the parmesan cheese and mozzarella cheese. Keep stirring until the cheese is melted and the sauce is smooth. If the sauce is too thick, add a bit of the reserved pasta water to loosen it up.

Step 5: Toss in the Pasta

Add the cooked bowtie pasta into the Alfredo sauce, stirring to coat each piece. Let it simmer for 2–3 minutes so the pasta absorbs the sauce.

Step 6: Finish with Chicken and Garnish

Slice the cooked Cajun chicken and arrange it over the pasta. Sprinkle fresh chopped parsley and crushed red pepper flakes (if using) over the top. Serve warm and creamy!

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How to Serve and Store Cheesy Garlic Cajun Chicken Bowtie Pasta in Alfredo Sauce

This pasta is best served fresh off the stove while it’s still creamy and hot. Pair it with a crisp green salad or roasted vegetables for a complete dinner. Garlic bread or a crusty baguette on the side? Absolutely encouraged to soak up any leftover sauce.

For leftovers, store the pasta in an airtight container in the refrigerator for up to 3 days. Reheat gently on the stove or microwave with a splash of milk or cream to loosen the sauce back up. Avoid freezing, as the creamy sauce can separate.

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Frequently Asked Questions

How spicy is this dish?

The heat level really depends on the Cajun seasoning you use. Some blends are mild while others bring the fire. You can always control it by adjusting the amount of cayenne or using a low-sodium/mild blend.

Can I use pre-cooked or rotisserie chicken?

Yes! While freshly seared Cajun chicken gives the best flavor, using shredded rotisserie chicken is a great shortcut. Just toss it with Cajun seasoning and warm it in the pan before adding to the pasta.

What other pasta shapes work well?

Fettuccine, penne, or rotini are great alternatives if you don’t have bowtie pasta on hand. The key is using a shape that holds the creamy sauce well.

Can I make it ahead of time?

You can prep the chicken and Alfredo sauce a day ahead. Store them separately and reheat gently before tossing with freshly cooked pasta.

Is there a dairy-free version?

Yes! Substitute the butter with vegan butter, the cream with full-fat coconut milk or a dairy-free alternative, and use vegan cheeses.

What vegetables can I add?

Sautéed spinach, mushrooms, or bell peppers make excellent additions. Add them in after the garlic and before the cream for a layered flavor boost.

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Want More Pasta Ideas with a Kick?

If you’re loving this Cheesy Garlic Cajun Chicken Bowtie Pasta in Alfredo Sauce, you’re in for a treat with these other flavorful dishes from the blog:

• Garlic Butter Chicken with Creamy Ricotta Alfredo Pasta for an extra cheesy spin.
• One Pot Creamy Spicy Cajun Chicken Sausage Mac if you’re in the mood for smoky, meaty comfort.
• Bowtie Pasta with Creamy Velveeta Beef Sauce for another bowtie beauty.
• Creamy Garlic Parmesan Tortellini with Chicken and Broccoli to sneak in a green veggie boost.
• Garlic Parmesan Beef Spaghetti Pasta for a hearty, beefy variation.

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Save This Pin + Share Your Results

📌 Save this recipe to your Pinterest dinner board so you can make it again and again.

And when you do, I’d love to hear how it turned out! Did you stick with the Cajun heat or tone it down a bit? Did you sneak in some veggies or add extra cheese?

Drop your experience in the comments—I read every one and love seeing your personal spins on these dishes.

👉 For even more creamy, spicy, and comforting dinner ideas, follow me on Pinterest here: Life with Nina on Pinterest

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