When comfort food meets bold Southern flavor, you get Cajun Chicken Rotini in Creamy Mozzarella Velveeta Sauce. This dish is a spicy, cheesy, and satisfying plate of pure indulgence that comes together with ease. Perfectly seasoned chicken bites seared to a golden crust, paired with creamy rotini pasta and smothered in a mozzarella-Velveeta sauce that’s rich, smooth, and laced with Cajun heat.

It’s a weeknight winner or a cozy weekend indulgence—ready in under 40 minutes but tastes like it came from your favorite Southern bistro. Whether you’re feeding a crowd or treating yourself, this pasta is guaranteed to steal the show. It’s hearty, flavorful, and unapologetically creamy.

What Kind of Chicken Should I Use for Cajun Chicken Rotini?

Boneless, skinless chicken breasts or thighs work best for this recipe. Thighs offer a juicier bite, while breasts are leaner and more neutral in flavor. Cube the chicken evenly to ensure consistent cooking and generous flavor coating with the Cajun spices.

Ingredients for the Cajun Chicken Rotini in Creamy Mozzarella Velveeta Sauce

Chicken: Boneless, skinless chicken breasts or thighs are the base of this hearty dish. You want juicy, flavorful bites that sear up perfectly.
Cajun Seasoning: This is where the magic starts. The Cajun blend gives the chicken that iconic spicy, smoky, and savory kick.
Rotini Pasta: The spiral shape of rotini holds onto the creamy sauce beautifully, making every bite loaded with flavor.
Velveeta Cheese: Velveeta melts down into a silky, dreamy sauce that coats the pasta perfectly.
Mozzarella Cheese: Mozzarella brings that gooey, stretchy cheese pull and balances the sharpness of Velveeta.
Heavy Cream: To thin out and enrich the cheese sauce, heavy cream is a must for creaminess.
Butter: Adds flavor depth and helps the sauce come together smoothly.
Parsley: A pop of green for garnish and freshness to contrast the rich flavors.

How To Make the Cajun Chicken Rotini in Creamy Mozzarella Velveeta Sauce

Step 1: Season and Sear the Chicken

Cut your chicken into bite-sized cubes. Generously season with Cajun seasoning, salt, and a pinch of black pepper. Heat a skillet over medium-high heat with a bit of oil and sear the chicken until golden brown and cooked through, about 6–8 minutes. Remove and set aside.

Step 2: Cook the Pasta

Bring a large pot of salted water to a boil. Add rotini pasta and cook until al dente, according to the package instructions. Drain and set aside, reserving 1/2 cup of the pasta water.

Step 3: Make the Creamy Cheese Sauce

In the same skillet you used for the chicken, lower the heat to medium and add butter. Once melted, pour in heavy cream and stir until warmed through. Add in the Velveeta cubes and shredded mozzarella, stirring constantly until completely melted and smooth. If the sauce is too thick, stir in a bit of the reserved pasta water.

Step 4: Combine Everything

Add the cooked rotini and seared chicken to the cheese sauce. Toss gently to coat everything in the sauce. Let it simmer for 2–3 minutes so the flavors meld.

Step 5: Garnish and Serve

Sprinkle chopped parsley over the top before serving for a touch of freshness and color. Serve hot and enjoy that creamy Cajun kick in every bite.

Serving and Storing Cajun Chicken Rotini

This dish is best enjoyed fresh off the stove while the sauce is hot and creamy. Pair it with a crisp green salad or garlic bread for a full, satisfying meal.

To store leftovers, place them in an airtight container and refrigerate for up to 3 days. Reheat gently on the stovetop or in the microwave with a splash of cream or milk to bring back the creamy texture.

For meal prepping, you can cook the chicken and pasta ahead of time and make the sauce fresh when you’re ready to serve. This helps preserve the sauce’s smooth, cheesy texture.

Frequently Asked Questions

Can I make this recipe less spicy?

Absolutely. Just reduce the amount of Cajun seasoning or use a milder version. You can also balance the heat with a little extra cream or mozzarella.

Can I substitute the Velveeta cheese?

Yes, but keep in mind Velveeta melts very smoothly. Cream cheese or a blend of cheddar and cream might work, though the texture may be slightly different.

Is this dish freezer-friendly?

While you can freeze it, the cream and cheese sauce may separate when reheated. It’s best enjoyed fresh or within a few days refrigerated.

What’s a good side dish with Cajun Chicken Rotini?

Try roasted vegetables, garlic knots, or a simple Caesar salad. Something light helps balance the richness.

Can I add vegetables to this recipe?

Yes! Spinach, bell peppers, or mushrooms would be great additions. Just sauté them in the skillet after searing the chicken.

Is this recipe gluten-free?

Not as written, but you can easily make it gluten-free by using gluten-free rotini pasta and checking your Cajun seasoning for additives.

Want More Pasta Dinner Ideas?

If you’re loving this Cajun Chicken Rotini, here are more pasta dinners packed with creamy sauces and big flavor:

For even more dinner ideas and daily inspiration, follow my recipe collection on Pinterest – Life with Nina.

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you keep it spicy or go mild? Try it with mushrooms or extra garlic?

I love seeing how you bring your own twist to these recipes. Questions and feedback are always welcome—let’s make cooking more delicious together!

Cajun Chicken Rotini in Creamy Mozzarella Velveeta Sauce

Author: Nina Johnson
Prep Time: 10 minutes
Cook Time: 25 minutes
Total Time: 35 minutes
Yield: 4 servings 1x
Category: Dinner
Method: Stovetop
Cuisine: Cajun-American

Print Recipe

Description

Creamy, spicy, and irresistibly cheesy—this Cajun Chicken Rotini in Creamy Mozzarella Velveeta Sauce is the ultimate comfort meal. Juicy Cajun-spiced chicken bites are tossed with rotini pasta and smothered in a luscious Velveeta-mozzarella sauce that clings to every twist of pasta. Whether it’s a cozy night in or meal prep for the week, this one’s a family favorite ready in under 40 minutes.

Instructions

1. Cut the chicken into bite-sized cubes. Season generously with Cajun seasoning, a bit of salt, and pepper.

2. In a skillet over medium-high heat with oil, sear the chicken pieces until golden and cooked through, about 6–8 minutes. Remove and set aside.

3. Bring a pot of salted water to a boil. Cook rotini until al dente. Reserve ½ cup pasta water, then drain the rest.

4. In the same skillet, reduce heat to medium. Add butter and melt. Stir in heavy cream. Once warm, add Velveeta and mozzarella. Stir continuously until the cheese is fully melted and the sauce is smooth. Add pasta water if needed to loosen the sauce.

5. Add the drained rotini and cooked chicken into the cheese sauce. Toss gently until well-coated. Let simmer for 2–3 minutes.

6. Sprinkle chopped parsley over the dish before serving. Enjoy immediately.